9/24/2023 0 Comments Ireal b pro andriodGlobal Eb, Bb, F and G transposition for horn players.Advanced practice settings (automatic tempo increase, automatic key transposition).Loop a selection of measures of a chart for focused practicing.Transpose any chart to any key or to number notation.Includes 50 exercises for practicing common chord progressions.Practice in the way, and at the level, that you choose Display scale recommendations for each chord of a song to help with improvisations.Look up piano, guitar and ukulele fingerings for any chord.Display guitar, ukulele tabs and piano fingerings for any of your chord charts. Improve your skills with the included chord diagrams
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“A year ago, our team would be sitting here solely talking about the game - and the game is important to us and we are ready for that,” said Charity Williams, who made powerful remarks on the importance of representation. This advertisement has not loaded yet, but your article continues below. As the entire team addressed the virtual gathering, captain Ghislaine Landry was adamant that four prepared questions be read in a specific order - meaning they’d make statements, both in English and French, on a bullying and harassment claim against their former coach, on racial equality and on the discovery of the remains of hundreds of Indigenous children in unmarked graves at residential school sites before talk turned to their preparation over the past 12 months. ‘We are more than athletes’: Canada’s Olympic rugby women open up about representation, Indigenous issues The Canadian women’s Olympic rugby team held a news conference early Saturday morning to talk about a variety of concerns on their minds going into the tournament. It was a business-like win in the end as the pair looks toward its next match against Germans Karla Borger and Julia Sude, which gets on airwaves Sunday at 11 p.m. But once you get out there and you play volleyball you just kind of forget about it.” In the warm-up we were just trying to shake it out. “I was shaking like a leaf,” Humana-Parades said after the match. Activate your Online Access Now Article content If you are a Home delivery print subscriber, unlimited online access is included in your subscription. Manage Print Subscription / Tax Receipt. 9/24/2023 0 Comments Aaron prodeusClassification of 184 p53 mutants are categorized into monomeric, dimeric and tetrameric protein species as predicted from crosslinking experiments. (A) Plot of transcriptional activity of selected p53 target genes performed in yeast using a missense mutation library in the OD of p53 (derived from data by Kato et al.). Retrospective analysis of transcriptional profiles of p53 oligomeric variants reveals that dimeric p53 mutants display selective gene expression. (E) Cellular expression of p53 oligomeric variants in H1299 cells at 24 hours (odd numbered lanes) and 48 hours (even numbered lanes) as analyzed by Western blot of cell lysates using an anti-p53 antibody (DO-1). (D) Schematic drawing of wt p53 and oligomeric variants. Western blot detection of p53 monomers and oligomers resolved by SDS PAGE following lysate treatment with 0.025% glutaraldehyde. (C) Glutaraldehyde crosslinking of p53 species isolated from H1299 cell lysates. A ribbon model of p53-CR illustrates the constructive charge interactions within the dimer-dimer interface of the p53 OD. (B) Amino acid sequence of the OD from p53-CR contains 3 charge-reversal mutations at positions 343, 346 and 351. Ribbon models of the predicted structure for 2 tandem ODs of p53-2OD as a dimer of monomers (blue and gray) were generated by homology modeling of the 1PES structure using SWISS-MODEL. (A) Amino acid sequence of the modified OD from p53-2OD contains 2 ODs (residues 310–360 of wt p53) separated by a glycine-threonine flexible linker. This study suggests that the most abundant oligomeric species of p53 present in resting cells, namely p53 dimers, neither promote cell growth or cell death and that shifting the oligomeric state equilibrium of p53 in cells toward monomers or tetramers is a key parameter in p53-based cell fate decisions.Īpoptosis cell cycle arrest cell fate oligomerization p53 tumor suppressor. In particular, the expression of pro-arrest CDKN1A and pro-apoptotic P53AIP1 genes are important cell fate determinants that are differentially regulated by the oligomeric state of p53. In contrast, p53 tetramers induce rapid apoptosis and cell growth arrest, while a monomeric variant is functionally inactive, supporting cell growth. We report that dimeric p53 variants are cytostatic and can arrest cell growth, but lack the ability to trigger apoptosis in p53-null cells. Here, we use 5 oligomeric variants of p53, including 2 novel p53 constructs, that yield either monomeric, dimeric or tetrameric forms of p53 and demonstrate that they induce distinct cellular activities and gene expression profiles that lead to different cell fate outcomes. How p53 chooses between these cell fate outcomes remains unclear. Activation of p53 through tetramerization is required for its tumor suppressive function by inducing transcriptional programs that lead to cell fate decisions such as cell cycle arrest or apoptosis. These mutations typically alter the oligomeric state of p53 and impair its transcriptional activity. Mutations in the oligomerization domain of p53 are genetically linked to cancer susceptibility in Li-Fraumeni Syndrome. Everyone else would probably prefer a more user-friendly alternative. TestDisk's Photorec "sibling" is an excellent solution for everyone familiar with tech-lingo and fond of keyboard-driven shell-based apps. And that one can locate and recover a wide range of files quickly and, best of all, for free. 12 Best Free USB Recovery Software in 2023 Which is the best free USB data recovery software for Mac or Windows 11/10/7 Here are the top 12 USB recovery tools free in 2023 for your reference. TestDisk is an app for "fixing" partitions, not bringing back files. It can recover files from hard drives, external drives ( USB drives, etc.), BD/DVD/CD discs, and memory cards. It's very easy to use, but has many optional advanced features as well. It lacks features, a modern interface, and doesn't produce the best results at acceptable speeds. Recuva is the very best free data recovery software tool available, hands down. However, today, Restoration lags far behind the competition. Do you need such extensive support for lesser-known file formats? Then, maybe the app's higher price (compared to competitors like Disk Drill) will be worth it. That's thanks to its support for more than a thousand file signatures. That should be enough to warrant a try to check how many of your files it can find.Įven if your data is stored in some obscure format, Data Recovery Wizard will probably recognize it. Lazesoft is a completely free data recovery software for Mac that lets you recover an unlimited amount of data without paying a single dollar. EaseUS Data Recovery WizardĮaseUS's Data Recovery Wizard can usually get back most files from a problematic piece of storage. Complete the unlimited data recovery software free download - EaseUS Data Recovery Wizard and use it to recover deleted or lost files. However, it would be best to look elsewhere if your storage device's condition is rapidly deteriorating, and you need to save your files as soon as possible. You can try it to seek some deleted files. It might miss some files and fail to recover others. The formerly popular data recovery app may frequently falter. However, in its current state, it seems as if its glory days are behind it. PhotoRec may be proved as the best free digital photo recovery software if none of your methods worked. It is used to recover photos corrupted or lost from your PC, Laptop, SD card, memory card, digital cameras, CD ROMs, etc. In most data loss scenarios, this was more than enough. PhotoRec comes under the category of USB data recovery free software which you will find online. Thanks to its mind-numbingly simple interface and zero limitations, Recuva justifiably became one of the most popular data recovery solutions. Its straightforward and affordable pricing is the icing on the cake. The best overall free data recovery program is Recoverit, it is one of the most reliable and effective data recovery software, which offers advanced solutions. It's easy to use but hides a powerful recovery engine and many useful features under the hood. With the free trial version, you can test while covering up to 2GB of data. A quick look at the table above shows why Disk Drill almost always dominates most "best data recovery apps" lists: it ticks nearly all boxes. EaseUS Data Recovery Wizard offers one of the simplest methods to recover data. 9/24/2023 0 Comments 62m iconiq growthsawersventurebeat“Highspot epitomizes our focus on clear product leaders that can make a global impact,” said ICONIQ Capital General Partner Matthew Jacobson, who is joining Highspot’s Board of Directors. We make our users trusted advisors to their customers, which is a real competitive advantage.” Now, more than ever, customer-facing teams need a system of truth for content and guidance. “Sales technology is moving toward a system of intelligence and collaboration. “Enablement is the new customer battleground,” said Highspot CEO Robert Wahbe. According to Gartner research: “By 2021, 15 percent of all sales technology investments will be applied to sales enablement technology, up from the 2017 level of 7.2 percent.” (Gartner, “Market Guide for Digital Content Management for Sales,” Guneet Bharaj, Theodore Travis, Melissa Hilbert, Todd Berkowitz, 16 October 2018) Highspot’s platform combines sophisticated machine learning and intuitive user experience to define modern sales enablement. SiriusDecisions reports, “65 percent of content produced by marketing for use by sales is never utilized.” Highspot is uniting sales and marketing in delivering personal, relevant customer conversations. The gap between sales and marketing is a decades-old challenge that traditional technologies have failed to reconcile. Hundreds of companies are using the Highspot platform to empower customer-facing teams and partners, elevate the customer experience, and ultimately, accelerate revenue growth. Highspot’s revenue, customer base, existing customer expansion and employee count are all more than doubling year-over-year. The investment will fuel Highspot’s global expansion and further extend its technology leadership in the sales enablement category. ICONIQ Capital led the round, with participation from new investor Sapphire Ventures and all existing investors including Madrona Venture Group, OpenView, Salesforce Ventures and Shasta Ventures. SEATTLE, J– Highspot, the highest customer-rated sales enablement platform, today announced it has secured $60 million in Series D funding. Technology Leader in Burgeoning Sales Enablement Category Is More Than Doubling Across Key Business Metrics 9/23/2023 0 Comments Whitney houston debut albumSo "Whitney" reprises a great voice being wasted on the slightest material. Anyone who recognized the scope of her talent couldn't wait to hear her sing some songs of real substance, but when you sell 14 million copies of an album, your record company doesn't want you tinkering around with the formula too much. On her first album, Houston's dazzling voice and surprisingly mature instincts far overshadowed her material. With seemingly no effort, she glides through improvised embellishments that seem like confessional sighs. The 23-year-old Houston, who performs at the Merriweather Post Pavilion July 11 and 12, is a once-in-a-generation singer not only does she have a huge voice with an enormous range, but she already has such command of it that she can soften even the biggest moments to give them a tender, sensual feel. Ironically, the success of Houston's debut album could end up crippling her career. "Whitney" delivers the genuine pleasure of a rare talent, but the follow-up album is so predictable that all the surprise and innocence of the original are gone. Nonetheless, no record has more slavishly imitated the original model than Houston's own follow-up: "Whitney" (Arista AL-8405).įrom its title and producers to its pacing and sound, Houston's second album sticks to the formula of her first. Look out, because here they come - Whitney-clone debut albums by Tawatha Agee, La La, Regina Belle and Peggi Blu have already come out this year, and more are on the horizon. 1 singles, every record company scrambled to come up with its own gorgeous young black woman who could sing sentimental pop ballads in a big, gospel-trained voice. When the 1985 debut album "Whitney Houston," sold 14 million units and produced four No. If there's one thing the American music industry knows how to do, it's how to imitate success. 9/23/2023 0 Comments Freenas cifs permissionsUsers 1 and 2 have almost feline levels of unreliability in reproducing the results of their samba fuzzing and almost feline levels of indignation when I try to get their fuzzing methods from them (they think I'm mocking their ability to properly use a computer). The problem didn't seem to appear if the dataset was owned by a user who didn't have an identically-named primary group. Then in typical samba fashion (2+2 = 15), I ended up with random "deny" ACE being generated for the file owner with a few other random ACEs being generated for good measure. Or if their login/password is not the same as the FreeNAS user created that they could map the drive using the FreeNAS user/group that has access to the share.# group: evidently, samba got confused by the lack of ACE in the root directory of the share when file ownership changed through user1 generating a new file. My original plan was to have one share and when any one on the local network hit the nas box "storageserver" from windows network that it would then take them in and show them the various shares and if their login matched the user/group assigned to the share it would let them in. As you can see in the video example "gbcsecurity" has read/write access to the folder "Security - Directory" but when I try to access the share as that user it fails to authenticate. In my youtube example I broke the individual folders into separate shares thinking that might make a difference but it doesnt. When I went to Windows to modify the security permissions I would add certain users or groups to the folders inside the share but could never access them. When I was logged in with local account "btotel" which is also the data set owner I can access all the shares just fine. Hi Mirfster, I orginally had one share which was to the "data_pool" level. I am hoping this is something I am not doing properly that this community can help me fix. Question 2: Why wont my users be able to access folders they have permissions to? Question 1: What should the permissions be on the root of the CIFS Share. This works great for the owner ID as I am logged in using the same ID but if any one else tries to authenticate to the share to access folder they have rights to in the CIFS share it wont connect. So what I am left with is the owner and group owner from FreeNAS. I have been removing the everyone as I dont want everyone to have access. The problem I have today is whenīy default FreeNAS creates the everyone, owner, and group ID from FreeNAS. In theory when a user hits the share it will promt them to provide credentials to allow them access to the folders they have rights to below. I have that I want to either Block access to, Read, and Read/Write access to on various folders in the CIFS share. I know how to modify windows permissions but here is where my problem begins. The PC I am logged onto is using the user ID and password matching the user ID created in FreeNAS so when I touch the share I have instant access to the share. The dataset permissions are set to Windows with my user ID "admin" as the owner and the group ID "Group" I have created a CIFS share to DataPool and I am able to see CIFS share in Windows. I have one data set called DataPool that has 10 folders as part of the data set. If I can explain what I am trying to do I hope that someone can tell me where I am going wrong in my logic. Hello all, I am having some issues, either technical or my own stupidity regarding permissions for accessing shares through CIFS. 9/23/2023 0 Comments Wood and marble bookendsWest elm also has all the furnishings you need for a comfortable, well-equipped home, including sofas, chairs and tables in every style. You may also want to check out the other decorative items, which range from traditional to modern. For example, if you opt for a set crafted from marble and wood, you could reflect the style throughout the room with other wood and marble accents, such as a marble floating shelf or one of the decorative objects at west elm that are crafted from wood.Įxplore the selection of bookends at west elm to find an array of stylish options. You can pair these book holders with other home accent items for a coordinated look. West elm has artificial plants and flowers that look just like the real thing. 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Traditionally, these items are used to hold books upright, but you can also use them to hold magazines. There are lots of ways to decorate your home with bookends. There are even sets crafted from lava rock, with natural variations that make each set unique. When it comes to materials, some of the options include stone, wood and metal. Whether you use these beautiful bookends to gather cookbooks on. These home accent items come in a variety of shapes, sizes and colors to coordinate with your decor. Our Marble With Wood Bookends will keep your books upright and show off your personal style. Purchase modern bookends such as gold bookends and others now for your clients.Accent any room of your home with a set of bookends from west elm. The color of the wood used is sometimes polished and allowed as the color of the bookend.Ī provides recreational marble bookends products for not only holding books, but beautifying spaces. FREE shipping Add to Favorites Personalized Marble Bookends, Housewarming Gift, Home Office Decor, Lawyer Gift, Bookshelf Decor (997) 69. The type of wood the bookend is made of goes a long way in determining its price and how much weight it can carry. Marble Bookends Handcrafted Heavy Triangular Bookshelf Decor Brass Inlay Set of 2 Decorative Book Stoppers Non-Skid Bottom Shelves Triangle (272) 53.41. You can also make the whole shelf look vintage with wooden bookends. You can now get agate bookends, geode bookends, star wars bookends, and various other types of book stoppers which are built to hold your books and even other items while representing furniture that matches your interior design. These can be very practical if your customers are libraries or librarians. Wholesale marble bookends can also come in the form of metal bookends which may be able to support greater weight and volumes. There are also other cool bookends you can get at awesome bargains here on. You can get jungle bookends to embellish your bookshelves and cupboards as they hold your books together in an orderly fashion. There are also many other styles of wholesale marble bookends you can consider, depending on your customers' likely preferences. Does Chairish have marble bookends on sale Yes We have 50+ marble bookends on sale. Marble bookends are stylishly designed with some extra touch of luxury to fit every context. Marble bookends range in price from 20 to 4,500 What are some popular marble bookend styles Popular marble bookend styles are Mid-Century Modern, Modern, and Traditional. Marble bookends are specially designed to not only be very instrumental but also be very beautiful, creating an amazing sight where it is placed. Get wholesale marble bookends for holding books in libraries, homes, and offices. 9/23/2023 0 Comments Autumn fern houseplantThe spores of this plant tend to drop in late summer, so you’ll need to be vigilant around this time. Within the prothallus, sperm fertilizes an egg and results in a sporophyte, which develops into a full-grown plant… and presto! The cycle continues. A prothallus develops organs that produce ova and antheridia, aka egg and sperm cells. On the underside of a fern’s fronds are sori, and each sorum contains sporangia.Įach sporangium produces spores, which release from the fronds, land elsewhere, and germinate into small, heart-shaped structures called prothalli. Ready to learn how to grow your own? Here’s what we’ll cover in this guide: erythrosora an undoubtedly worthy planting. Both colors offer a nice change of pace from the green shades seen in other ferns.Īlong with its unique color scheme, toughness, and a compact growing habit make D. Which is fine, because a fern’s green foliage is just what the doctor ordered… most of the time.īut it’s not horticultural heresy to look at a fern, sigh in discontentment, and think: Plain old green again? Can’t a gardener get a different shade of fern up in here, for a change? With the autumn fern, you actually can.Īutumn ferns, aka copper shield or Japanese wood ferns, actually start out their growth in spring with a coppery tint to their foliage, then mature to sport a more yellowish-green hue as the growing season progresses. Since they don’t flower, their fronds are all that they have, ornamentally. Įven among plants, ferns are well-known for their greenery. If you buy from one of our links, we may earn a commission. We link to vendors to help you find relevant products. 9/23/2023 0 Comments Yu chen
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